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NITRIC OXIDE
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DeCS
Descriptor
English
:
Nitric Oxide
Descriptor
Spanish
:
Óxido Nítrico
Descriptor
Portuguese
:
Óxido Nítrico
Tree Number:
D01.339.387
D01.625.550.500
D01.625.700.500
D01.650.550.587.600
Definition
English
:
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from
ARGININE
by
NITRIC OXIDE SYNTHASE
.
Nitric oxide
is one of the
ENDOTHELIUM-DEPENDENT RELAXING FACTORS
released by the vascular
endothelium
and mediates
VASODILATION
. It also inhibits
platelet aggregation
, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular
endothelium
.
Nitric oxide
activates cytosolic
GUANYLATE CYCLASE
and thus elevates intracellular levels of
CYCLIC GMP.
Pharmacological Action:
Bronchodilator Agents
Endothelium-Dependent Relaxing Factors
Free Radical Scavengers
Gasotransmitters
Neurotransmitter Agents
See Related
English
:
Endothelium-Dependent Relaxing Factors
Nitric Oxide Donors
History Note
English
:
1965
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
9753
Unique Identifier:
D009569
Occurrence in VHL
:
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DeCS
CID-10
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